AZD3988

SKU: orb1707610

Description

AZD3988 is a potent and orally bioavailable small molecule inhibitor of diacylglycerol acyltransferase-1 (DGAT-1). It is a valuable research tool for investigating metabolic disorders, enabling studies on lipid metabolism and energy homeostasis in both in vitro and in vivo models of diabetes and obesity.

Research Area

Metabolism Research

Key Properties

• CAS Number: 892489-52-0
• MW: 456.44
• Purity: 99.82% (May vary between batches)
• Formula: C₂₃H₂₂F₂N₄O₄
• SMILES: OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(NC(=O)c2nnc(Nc3ccc(F)c(F)c3)o2)cc1
• Target: Acyltransferase,Transferase
• Solubility: DMSO:10 mg/mL (21.91 mM)

Bioactivity

• Target IC50:
  DGAT-1 (rat):5 nM|DGAT-1 (mouse):11 nM|DGAT-1 (human):6 nM|DGAT-1 (human):6 nM
• In Vitro:
  In mice, rats, and dogs, AZD3988 (0.5, 1, 2, 5 mg/kg; intravenous injection) exhibited good bioavailability.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

h DGAT-1, Mouse DGAT-1, AZD3988, AZD-3988, AZD 3988, DGAT1, Rat DGAT-1

Compound Identifiers

PubChem CID

23648867