AZD1152-HQPA

SKU: orb1224146

Description

The active product of AZD1152, a potent, selective inhibitor of Aurora B kinase with IC50 of 0.37 nM; displays >3,700-fol selectivity for Aurora B over Aurora A; potently inhibits the growth of human colon, lung, and hematologic tumor xenografts.

Key Properties

• CAS Number: 722544-51-6
• MW: 507.5599
• Purity: >98% (HPLC)
• Formula: C₂₆H₃₀FN₇O₃
• SMILES: O=C(NC1=CC=CC(F)=C1)CC2=CC(NC3=C4C=CC(OCCCN(CC)CCO)=CC4=NC=N3)=NN2
• Target: Aurora Kinase
• Solubility: 10 mM in DMSO

Bioactivity

• In Vitro:
  Cell Proliferation Assay. Cell line: AML lines (HL-60, NB4, MOLM13), ALL line (PALL-2), biphenotypic leukemia (MV4-11), acute eosinophilic leukemia (EOL-1), and the blast crisis of chronic myeloid leukemia K562 cells. Concentration: 0-100 nM. (Barasertib -HQPA) Incubation time: 48 h. Result: IC50 values ranged from 3 nM to 40 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Barasertib | AZD2811

Quick Database Links

Gene Symbol

Aurora Kinase