AZD0095

SKU: orb1685673

Description

AZD0095 is a potent and selective MCT4 inhibitor exhibiting an IC50 of 1.3 nM. It is a valuable research tool for studying monocarboxylate transporter biology in vitro and has been utilized in preclinical models to investigate cancer metabolism and tumor microenvironment.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2750001-23-9
• MW: 500.6
• Purity: 98.51% (May vary between batches)
• Formula: C₂₇H₃₂N₈O₂
• SMILES: Cc1nc2nc(C)c(O[C@@H]3CCN(C3)c3ccc(cc3)-c3ccc(CN4CCOCC4)nn3)c(C)n2n1
• Target: Monocarboxylate transporter
• Solubility: DMSO:6.2 mg/mL (12.39 mM)

Bioactivity

• Target IC50:
  MCT4:1.3 nM
• In Vivo:
  Oral administration of AZD0095 (100 mg/kg) and Cediranib inhibit the growth of tumors in NCI-H358 xenograft in mice.
• In Vitro:
  AZD0095 (0-50 µM) inhibits the proliferation of NCI-H358 cells with an IC50 of 26 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZD0095, AZD-0095, AZD 0095, Monocarboxylatetransporter, Monocarboxylate transporter, MCT4

Compound Identifiers

PubChem CID

146241312