AZD-5069

SKU: orb1299597

Description

AZD-5069 is a potent and selective small molecule antagonist of the CXCR2 chemokine receptor, exhibiting an IC50 of 0.79 nM. It has been utilized in preclinical research to investigate the role of CXCR2 in inflammatory diseases, including studies in models of COPD, asthma, and cancer.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 878385-84-3
• MW: 476.52
• Purity: 98.63%
• Formula: C₁₈H₂₂F₂N₄O₅S₂
• SMILES: C[C@@H](Oc1cc(NS(=O)(=O)N2CCC2)nc(SCc2cccc(F)c2F)n1)[C@@H](O)CO
• Target: CXCR
• Solubility: DMSO:90 mg/mL (188.87 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.93 mM)

Bioactivity

• Target IC50:
  CXCR2:0.79 nM
• In Vitro:
  AZD5069 inhibited neutrophil chemotaxis, with a pA2 of approximately 9.6, and adhesion molecule expression, with a pA2 of 6.9, in response to CXCL1

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CXCR2, CXC chemokine receptors, CXCR, AZD5069, AZD-5069, AZD 5069, Inhibitor, inhibit

Compound Identifiers

PubChem CID

56645576