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AZD-3759

SKU: orb1226032

Description

A potent, oral active, BBB-penetrating EGFR inhibitor (IC50=7.2 nM, L858R pEGFR); fully penetrate the blood-brain barrier (BBB), with equal free concentrations in the blood, cerebrospinal fluid, and brain tissue; causes tumor regression in subcutaneous xenograft, leptomeningeal metastasis (LM), and brain metastasis (BM) lung cancer models and prevents the development of BM in nude mice.Lung Cancer Phase 1 Clinical.

Images & Validation

Key Properties

CAS Number1626387-80-1
MW459.9011
Purity>98% (HPLC)
FormulaC22H23ClFN5O3
SMILESO=C(N1[C@H](C)CN(C)CC1)OC2=CC3=C(NC4=CC=CC(Cl)=C4F)N=CN=C3C=C2OC
TargetEGFR
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AZD-3759

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AZD-3759 (orb1226032)

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200 mg
500 mg
10 mg
$ 80.00
25 mg
$ 110.00
50 mg
$ 140.00
100 mg
$ 190.00