AZD 3147

SKU: orb1693948

Description

AZD 3147 is a potent and selective mTORC inhibitor, demonstrating IC50 values of 5.75 nM for mTORC2 and 40.7 nM for mTORC1, with significantly lower activity against PI3K isoforms. This selectivity profile makes it a valuable chemical probe for studying mTOR signaling in cancer research and cellular biology, applicable in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1101810-02-9
• MW: 517.66
• Purity: 99.99%
• Formula: C₂₄H₃₁N₅O₄S₂
• SMILES: S(=O)(=O)(C1(CC1)C=2C=C(N=C(N2)C3=CC=C(NC(NCCO)=S)C=C3)N4[C@@H](C)COCC4)C5CC5
• Target: mTOR
• Solubility: Hydrochloride acid:100 mg/mL (193.18 mM);Ethanol:1 mg/mL (1.93 mM);DMSO:46.8 mg/mL (90.41 mM)

Bioactivity

• In Vivo:
  AZD3147 shows a CL of 78 mL/min/kg, a Vss of 2.3 L/kg, a t1/2 of 0.9 h and an F of 61% in mice.
• In Vitro:
  In NIH3T3 cells, AZD3147 (1.5-50 nM) alleviates FGF-mediated cilia extension. AZD3147 inhibits cell viability of neuroblastoma cell lines Kelly(IC50 = 0.88 nM) and IMR-32 (IC50 = 662.4 nM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZD3147, AZD-3147, AZD 3147, mTORC1, mTORC2

Compound Identifiers

PubChem CID

25168990