AZD-2461

SKU: orb1305416

Description

AZD2461 is a potent and selective small molecule inhibitor of poly(ADP-ribose) polymerase (PARP). It is a valuable research tool for investigating DNA damage response pathways, with utility in both in vitro cellular assays and in vivo xenograft models for oncology research.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1174043-16-3
• MW: 395.43
• Purity: 99.87%
• Formula: C₂₂H₂₂FN₃O₃
• SMILES: COC1CCN(CC1)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F
• Target: PARP
• Solubility: Ethanol:39.5 mg/mL (99.89 mM);DMSO:45 mg/mL (113.8 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.06 mM)

Bioactivity

• Target IC50:
  PARP3:200 nM|PARP2:2 nM|PARP1:5 nM
• In Vivo:
  AZD2461 had a lower affinity for Pgp than olaparib.
• In Vitro:
  AZD2461 had a lower affinity for Pgp than olaparib.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZD 2461, AZD2461, AZD-2461, Inhibitor, inhibit, PARP, poly ADP ribose polymerase

Compound Identifiers

PubChem CID

44199317