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AZD-1480

SKU: orb1223598

Description

A potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM; demonstrates significant JAK2 selectivity over JAK3 and marginal selectivity over JAK1; blocks STAT3 phosphorylation in a panel of human solid tumor cell lines, potently inhibits the growth of the TEL-Jak2 cell line (GI50=60 nM); suppresses the growth of human solid tumor xenografts harboring persistent Stat3 activity.Liver Cancer Phase 1 Discontinued.

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Key Properties

CAS Number935666-88-9
MW348.766
Purity>98% (HPLC)
FormulaC14H14ClFN8
SMILESCC1=CC(NC2=NC(N[C@H](C3=NC=C(F)C=N3)C)=NC=C2Cl)=NN1
TargetJAK
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AZD1480 | AZD 1480

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AZD-1480 (orb1223598)

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5 mg
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