AZD-0156

SKU: orb1225871

Description

AZD-0156 (AZD0156, AZD 0156) is a potent, highly selective and orally bioavailable ATM inhibitor; exhibits antitumoral activity, both reducing tumor burden and preventing tumors from growing in an immunocompetent allograft mouse model of AML.Solid Tumors Phase 1 Clinical(In Vitro):AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.

Key Properties

• CAS Number: 1821428-35-6
• MW: 461.556
• Purity: >98% (HPLC)
• Formula: C₂₆H₃₁N₅O₃
• SMILES: O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=C(OCCCN(C)C)N=C5)=CC=C4N=C3
• Target: ATM/ATR
• Solubility: DMSO: 6.2 mg/mL (Need ultrasonic and warming)

Bioactivity

• In Vitro:
  AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZD0156 | AZD 0156

Quick Database Links

Gene Symbol

ATM/ATR