Azadiradione

SKU: orb1297018

Description

Azadiradione (AZD) is a limonoid isolated from the seeds of Azadirachta indica (neem). It is a research compound of interest in studies of inflammation and metabolic disorders, with demonstrated activity in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 26241-51-0
• MW: 450.57
• Purity: 99.91% (May vary between batches)
• Formula: C₂₈H₃₄O₅
• SMILES: C[C@]12C=3[C@](C)([C@@H](C(=O)C3)C=4C=COC4)CC[C@@]1([C@]5(C)[C@@](C[C@H]2OC(C)=O)(C(C)(C)C(=O)C=C5)[H])[H]
• Target: Others,HSP
• Solubility: DMSO:55 mg/mL (122.07 mM)

Bioactivity

• In Vitro:
  Azadiradione (AZD) ameliorates toxicity due to protein aggregation in cell and fly models of polyglutamine expansion diseases to a great extent. All these effects are correlated with activation of HSF1 function and expression of its target protein chaperone genes. Notably, HSF1 activation by AZD is independent of cellular HSP90 or proteasome function. Furthermore, we show that AZD directly interacts with purified human HSF1 with high specificity, and facilitates binding of HSF1 to its recognition sequence with higher affinity. These unique findings qualify AZD as an ideal lead molecule for consideration for drug development against NDs that affect millions worldwide.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

bioactive limonoid, Azadiradione, anti-nociceptive, anti-inflammatory activities, antimycobacterial, AZD, inhibit, Inhibitor, Heat shock proteins, HSF1 Activator, HSP

Compound Identifiers

PubChem CID

12308714