Azadirachtin B

SKU: orb1707616

Description

Azadirachtin B (Deacetylazadirachtinol) is a bioactive terpenoid isolated from neem seeds. It exhibits insecticidal, anticancer, anti-inflammatory, and antiviral properties, making it a valuable research tool for studying viral infections and cancer biology in vitro. Studies also indicate it can promote osteoblast proliferation and differentiation.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 106500-25-8
• MW: 662.68
• Formula: C₃₃H₄₂O₁₄
• SMILES: [H][C@@]12OC=C[C@]1(O)[C@@H]1C[C@H](O2)[C@]2(O[C@@]12C)[C@]1(C)[C@H](O)[C@]2([H])OC[C@@]3([C@@H](C[C@H](O)[C@@]4(CO[C@H](C(=O)OC)[C@@]14[H])[C@@]23[H])OC(=O)C(\C)=C\C)C(=O)OC
• Target: Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.02 mM);DMSO:40 mg/mL (60.36 mM)

Bioactivity

• In Vivo:
  Azadirachtin B (oral) has antitumor activity against peroxynitrite (ONOO-) -induced skin tumors in mice.
• In Vitro:
  Azadirachtin B increases expression of RunX-2 ∼2.5 fold at 10 nM concentration, ALP expression ∼2.8 fold at 10 nM and 100 pM concentration and OCN expression ∼2.5 folds at 10 nM as compared with control. Azadirachtin B exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32 pmol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA). Azadirachtin B exhibits toxicity to the diamondback moth (Plutella xylostella) with an LD50 of 4.85-1.06 µg/g body weight, in 92 h.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Azadirachtin B, Alkaline phosphatase (ALP), 3-Tigloylazadirachtol, Deacetylazadirachtinol, Plutella xylostella

Compound Identifiers

PubChem CID

172899191