AZA1

SKU: orb1688587

Description

AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of the Rho GTPases Rac1 and Cdc42. This small molecule induces apoptosis and suppresses proliferation, migration, and invasion in prostate cancer cells in vitro, supporting research in oncology and cell signaling pathways.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1071098-42-4
• MW: 368.43
• Purity: 99.75% (May vary between batches)
• Formula: C₂₂H₂₀N₆
• SMILES: Cc1cc2cc(Nc3ccnc(Nc4ccc5[nH]c(C)cc5c4)n3)ccc2[nH]1
• Target: Rho,CDK,Ras,Apoptosis
• Solubility: DMSO:60 mg/mL (162.85 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.43 mM)

Bioactivity

• In Vivo:
  AZA1 (Rac1/Cdc42-IN-1) (100 μg; i.p.; daily for 2 weeks) effectively suppresses human 22Rv1 xenograft growth in 5-week-old athymic nu/nu (nude) mice and improves survival, with a significant impact on tumor growth suppression.
• In Vitro:
  AZA1 (Rac1/Cdc42-IN-1) (2-10 μM; 72 hours) impedes the proliferation of human 22Rv1 prostate cancer cells, diminishes phosphorylation of PAK1, AKT, and BAD in EGF-stimulated 22Rv1 cells (2-10 μM; 24 hours), and obstructs Rac1 and Cdc42-dependent cell cycle progression (10 μM; 24 hours). AZA1 also inhibits Rac1 and Cdc42-dependent migration of 22Rv1, DU 145, and PC-3 prostate cancer cells, impacting cell motility and actin reorganization through PAK1/2 phosphorylation suppression.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, AZA 1, AZA1, AZA-1, cdc42, Rac1, Rac1/Cdc42-IN-1

Compound Identifiers

PubChem CID

25104141