AZ960

SKU: orb1223692

Description

A potent, selective JAK2 inhibitor with Ki of 0.45 nM, IC50 of <3 nM; displays 3-fold selectivity over JAK3 (IC50=9 nM); blocks STAT5 phosphorylation and potently inhibits cell proliferation (GI50=25 nM) in TEL-JAK2 driven Ba/F3 cells, blocks BCL-XL, PIM1 and PIM2 mRNA expression and induces apoptosis; also induces growth arrest and apoptosis in adult T-cell leukemia cells; also inhibits parasite Trypanosoma brucei ERK8 (Ki=1.25 uM) with antiparasitic activity (IC50=120nM).Blood Cancer Preclinical.

Key Properties

• CAS Number: 905586-69-8
• MW: 354.3566464
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₆F₂N₆
• SMILES: N#CC1=C(N[C@H](C2=CC=C(F)C=C2)C)N=C(NC3=NNC(C)=C3)C(F)=C1
• Target: JAK
• Solubility: DMSO: ≥ 30 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZ-960 | AZ 960

Quick Database Links

Gene Symbol

JAK