AZ9482

SKU: orb1219278

Description

AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells.

Key Properties

• CAS Number: 1825345-33-2
• MW: 450.5
• Purity: >98% (HPLC)
• Formula: C₂₆H₂₂N₆O₂
• SMILES: O=C1NN=C(CC2=CC=CC(C(N3CCN(C4=NC=CC=C4C#N)CC3)=O)=C2)C5=CC=CC=C51
• Target: PARP
• Solubility: In Vitro: DMSO : 125 mg/mL (277.48 mM)

Bioactivity

• In Vivo:
  AZ0108 also displays toxicity In vivo, the molecular basis of which is currently undefined, limiting pharmacological evaluation of AZ0108.
• In Vitro:
  AZ9482 exhibits an EC50 of 24 nM in MDA-MB-468 cells. AZ0108 treatment prevents CHK1 MARylation and induces hyperphosphorylation of CHK1, contributing to MPS formation and dysregulation of the cell cycle. Cell Viability Assay Cell line: MDA-MB-468 cells. Concentration: 0-10 μM. Incubation time: 3 days. Result: EC50 was 24 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PARP