AZ82

SKU: orb1710353

Description

AZ82 is a potent and selective KIFC1 inhibitor that suppresses KIFC1 expression in prostate cancer (PCa) cells, leading to multipolar spindle formation, mitotic catastrophe, and apoptosis. It is a valuable chemical probe for studying mitosis and oncology research in vitro.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1449578-65-7
• MW: 560.63
• Purity: 99.31% (May vary between batches)
• Formula: C₂₈H₃₁F₃N₄O₃S
• SMILES: CCCc1cc(sc1C)C(=O)N[C@H](Cc1ccc(nc1)-c1cccc(OC(F)(F)F)c1)C(=O)N[C@@H]1CCNC1
• Target: Kinesin,Microtubule Associated
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.13 mM);DMSO:100 mg/mL (178.37 mM)

Bioactivity

• Target IC50:
  HSET/KIFC1:300 nM|HSET/KIFC1:43 nM (ki)|HSET/KIFC1:43 nM (Ki)
• In Vitro:
  AZ82 specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome numbers, such as HeLa . AZ82 binds specifically to KIFC1/MT complex but not to KIFC1 or MT alone. Treatment with AZ82 caused centrosome declustering in BT-549 breast cancer cells with amplified centrosomes. AZ82 inhibits both processes for mant-ATP binding/releasing (IC50: 0.90 μM/1.26 μM) .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZ82, AZ-82, AZ 82, MicrotubuleAssociated, Microtubule Associated, HSET, HSET/KIFC1

Compound Identifiers

PubChem CID

91885438