AZ3246

SKU: orb2944894

Description

AZ3246 is a potent and selective oral HPK1 inhibitor with sub-3 nM IC50, promoting IL-2 secretion in T cells (EC50 = 90 nM). This low-clearance compound is utilized in immuno-oncology research to study T-cell activation and antitumor responses in both cellular and in vivo models.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2893978-54-4
• MW: 471.44
• Purity: 99.40% (May vary between batches)
• Formula: C₂₁H₂₀F₃N₉O
• SMILES: O=C(N)C1=NC(=C(N=C1NC2=CN(N=C2C)CC(F)(F)F)C3CC3)C4=CN=CC5=C4N=CN5C
• Target: MAPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166485054