AZ31

SKU: orb1706019

Description

AZ31 is a potent, selective, and orally active ATM kinase inhibitor with excellent selectivity over related kinases. It acts as a radiosensitizer in vitro and has demonstrated efficacy in vivo, supporting its use in cancer research, particularly in studying DNA damage response pathways.

Research Area

Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 2088113-98-6
• MW: 420.5
• Purity: 98.01% (May vary between batches)
• Formula: C₂₄H₂₈N₄O₃
• SMILES: N([C@@H](C)C1CCOCC1)C=2C3=C(N=CC2C(N)=O)C=CC(=C3)C=4C=CC(COC)=NC4
• Target: ATM/ATR
• Solubility: DMSO:25 mg/mL (59.45 mM)

Bioactivity

• Target IC50:
  ATM:46 nM|ATM (oral):1.2 nM
• In Vivo:
  AZ31 (50-100 mg/kg ; p.o. twice daily) exhibits limited penetration into the brain.
• In Vitro:
  AZ31 (0.3-3 μM ; 1 h) modulates the phosphorylation of a range of ATM targets. AZ31 (10 μM ; 1 h) influences the stabilization of p53 in H2228 lung cancer cells post-radiation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ATR, ATM, AZ 31, AZ31, AZ-31

Compound Identifiers

PubChem CID

134694318