AZ14240475

SKU: orb2945613

Description

AZ14240475 is a brain-penetrant, selective small molecule inhibitor targeting EGFR exon 20 insertion mutants, exhibiting a pIC50 of 7.6. It is a valuable research tool for investigating this oncogenic driver in both cellular assays and in vivo preclinical models of non-small cell lung cancer.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• MW: 480.854
• Formula: C₂₃H₁₅ClF₂N₆O₂
• SMILES: C=CC(=O)N1CC2=C(C1)N(C(=N2)C3=CC(=C(C=C3F)F)OC4=NC=CC(=C4)Cl)C5=NC=NC=C5
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676880