AZ13705339

SKU: orb1701137

Description

AZ13705339 is a potent and selective PAK1/2 inhibitor with sub-nanomolar binding affinity. It is a valuable research tool for investigating PAK signaling in cancer biology, supporting both in vitro and in vivo experimental studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2016806-57-6
• MW: 629.75
• Purity: 99.77% (May vary between batches)
• Formula: C₃₃H₃₆FN₇O₃S
• SMILES: CCS(=O)(=O)c1cc(Nc2ncc(F)c(n2)N(Cc2ccccc2C#N)c2cc(CO)ccc2C)ccc1N1CCN(C)CC1
• Target: PAK
• Solubility: DMSO:225 mg/mL (357.28 mM)

Bioactivity

• Target IC50:
  pPAK1:59 nM|PAK1:0.28 nM (Kd)|PAK1:0.33 nM|PAK2:0.32 nM (Kd)
• In Vivo:
  In rats, AZ13705339 (100 mg/kg, p.o.) exhibits moderate clearance and Cmax of 7.7 μM.
• In Vitro:
  AZ13705339 (300 nM) prevents Siglec-8 binding-induced eosinophil death. In Namalwa cells, AZ13705339 (1 μM) inhibits αIgM-controlled but not PMA-induced adhesion.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PAK1, AZ13705339, AZ-13705339, AZ 13705339

Compound Identifiers

PubChem CID

129909860