AZ12672857

SKU: orb1297959

Description

AZ12672857 is a potent and selective EphB4 inhibitor with an IC50 of 1.3 nM. It effectively blocks EphB4 autophosphorylation and cellular proliferation in relevant assays, making it a valuable chemical probe for studying EphB4 signaling in cancer research and angiogenesis, both in vitro and in vivo.

Research Area

Cardiovascular Research, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 945396-55-4
• MW: 486.57
• Purity: 98.99% (May vary between batches)
• Formula: C₂₆H₃₀N₈O₂
• SMILES: CN(c1ccnc(Nc2cc(cc(c2)N2CCOCC2)N2CCOCC2)n1)c1cccc2[nH]ncc12
• Target: Src,Ephrin Receptor,Prostaglandin Receptor
• Solubility: DMSO:50 mg/mL (102.76 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.11 mM)

Bioactivity

• In Vitro:
  AZ12672857 shows IC50s of 240 nM and 58 nM for p-KDR in HUVEC and p-PDGFR-β in MG63 cell line. AZ12672857 moderately inhibits CYP P450 with IC50s of 5 μM for 2C9 and 3A4 and >10 μM for 1A4, 2D6 and 2C19.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

c-Src, AZ 12672857, AZ12672857, AZ-12672857, EphB4, EphrinReceptor, Ephrin Receptor

Compound Identifiers

PubChem CID

49831162