AZ PFKFB3 26

SKU: orb1308618

Description

AZ PFKFB3 26 is a potent and selective small molecule inhibitor of PFKFB3, exhibiting an IC50 of 23 nM. It demonstrates over 80-fold selectivity against PFKFB1 and PFKFB2. This inhibitor is a valuable research tool for studying glycolysis, angiogenesis, and cancer cell proliferation in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1704740-52-2
• MW: 402.49
• Purity: 99.85% (May vary between batches)
• Formula: C₂₄H₂₆N₄O₂
• SMILES: CC(C)Cn1cc(C#N)c2cc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc12
• Target: Autophagy,Glucokinase
• Solubility: DMSO:4.5 mg/mL (11.18 mM)

Bioactivity

• Target IC50:
  PFKFB2:0.384 μM|PFKFB1:2.06 μM|PFKFB3:23 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PFKFB1, PFKFB2, PFKFB3, AZ PFKFB3 26, AZ PFKFB-3 26, Autophagy, Inhibitor, inhibit

Compound Identifiers

PubChem CID

118735769