AZ-32

SKU: orb1219795

Description

AZ32 is an orally bioavailable and blood-brain barrier-penetrating inhibitor of ATM(IC50 of <6.2 nM and 0.31 μM for ATM enzyme and in cell)

Key Properties

• CAS Number: 2288709-96-4
• MW: 328.37
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₆N₄O
• SMILES: CNC(=O)c1ccc(cc1)c2cnc3cnc(cn23)c4ccccc4
• Target: ATM/ATR
• Solubility: DMSO:150 mg/mL (456.80 mM)

Bioactivity

• In Vivo:
  AZ32, with enhanced BBB penetration, is highly efficient In vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC50 for approximately 22 hours.
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• In Vitro:
  AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ATM/ATR