AZ-23

SKU: orb1940888

Description

AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.

Key Properties

• CAS Number: 915720-21-7
• MW: 391.83
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₉ClFN₇O
• SMILES: CC(C)Oc1n[nH]c(Nc(nc(N[C@@H](C)c(cc2)ncc2F)nc2)c2Cl)c1
• Target: Trk Receptor
• Solubility: DMSO:125 mg/mL (319.02 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  AZ-23 shows In vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma.
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• In Vitro:
  AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC50 of 2 nM). AZ-23 Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZ23 | AZ 23

Quick Database Links

Gene Symbol

Trk Receptor