AZ 14145845

SKU: orb2695176

Description

AZ 14145845 is a potent, orally bioavailable dual Mer/Axl kinase inhibitor. It demonstrates dose-dependent antitumor efficacy in Ba/F3 xenograft models and enhances survival in MC38 tumor models when combined with anti-PD1 therapy and radiation. This compound is a valuable research tool for investigating TAM kinase signaling in immuno-oncology and combination therapies.

Key Properties

• CAS Number: 2830555-70-7
• MW: 561.68
• Formula: C₃₂H₃₅N₉O
• SMILES: N=1N=C(OC1C=2N=CC(=CC2C)C=3C(=NN(C3C)C)C)N(C)CC=4C=CC5=NC=C(C=6C=CC(=CC6)CN(C)C)N5C4

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156596359