AZ-1355

SKU: orb1708050

Description

AZ-1355 is a dibenzoxepine-based small molecule compound exhibiting lipid-lowering activity. It is utilized in biochemical research to investigate metabolic pathways and has been evaluated in experimental models for its effects on dyslipidemia.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 75451-07-9
• MW: 299.32
• Purity: >99.99% (May vary between batches)
• Formula: C₁₇H₁₇NO₄
• SMILES: O(C)C1=C2C(CNC=3C(O2)=CC=C(C(OCC)=O)C3)=CC=C1
• Target: Prostaglandin Receptor
• Solubility: DMSO:22.5 mg/mL (75.17 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.34 mM)

Bioactivity

• In Vivo:
  AZ-1355 consistently decreases serum total cholesterol (TC) in Triton-induced hyperlipidemic mice at a dose of 150 mg/kg. At a lower dose of 50 mg/kg, it significantly lowers serum triglycerides (TG), while a 100 mg/kg dose effectively reduces both serum TC and TG in rats. Additionally, the 100 mg/kg dosage diminishes total liver TC in rats consuming a CE-2 diet, and a 50 mg/kg dose not only reduces liver TC in rats on a high-fat diet but also decreases total hepatic TG in CE-2 fed rats.
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• Cell Research:
  The lipid-lowering profile in rodents AZ-1355, A New Dibenzoxazepine Derivative
• Animal Research:
  AZ-1355 (150 mg/kg) reproducibly lowers serum total cholesterol (TC) in the Triton hyperlipidemic mice. AZ-1355 (50 mg/kg) significantly reduces serum TG and the 100 mg/kg dose results in serum TC and TG reduction in rats. AZ-1355 (100 mg/kg) reduces total liver TC in rats fed CE-2, and the 50 mg/kg dose reduces hepatic TC in rats fed the high-fat diet on both bases, and it also reduces the total hepatic TG of the CE-2 fed rats.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ProstaglandinReceptor, Prostaglandin I2, Prostaglandin Receptor, Thromboxane A2, AZ 1355, AZ1355, AZ-1355

Compound Identifiers

PubChem CID

339237