Ayanin

SKU: orb1297456

Description

Ayanin is a vasorelaxant and non-selective phosphodiesterase 1-4 inhibitor with potential for allergic asthma research. It inhibits IL-4 production in basophils with an IC50 of 2.2 µM, supporting its study in respiratory disease models both in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 572-32-7
• MW: 344.32
• Purity: 99.65% (May vary between batches)
• Formula: C₁₈H₁₆O₇
• SMILES: COc1cc(O)c2c(c1)oc(-c1ccc(OC)c(O)c1)c(OC)c2=O
• Target: Cytochromes P450,PDE,IL Receptor,PARP
• Solubility: 10% DMSO+90% Saline:3.3 mg/mL (9.58 mM);DMSO:245 mg/mL (711.55 mM)

Bioactivity

• Target IC50:
  IL-4:2.2 μM
• In Vitro:
  Incubation of human leukemia cells with Ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-x(L). Ayanin diacetate-induced cell death was found to be associated with: (i) loss of inner mitochondrial membrane potential, (ii) the release of cytochrome c, (iii) the activation of multiple caspases, (iv) cleavage of poly(ADP-ribose) polymerase and (v) the up-regulation of death receptors for TRAIL, DR4 and DR5. Moreover, the combined treatment with Ayanin diacetate and TRAIL amplified cell death, compared to single treatments.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, hypertension, IL Receptor, PARP, PDE2A, PDE4, ILReceptor, inhibit, Ayanin, allergic asthma, airway hyperresponsiveness, P450, Phosphodiesterase (PDE), tracheal relaxant, respiratory disease

Compound Identifiers

PubChem CID

5280682