AX-024

SKU: orb1688965

Description

AX-024 is a potent and selective orally bioavailable small molecule inhibitor of the TCR-Nck interaction, targeting SH3 domains to suppress T cell activation. With an IC50 of ~1 nM, it effectively reduces pro-inflammatory cytokine production (e.g., IL-6, TNF-α, IFN-γ) and demonstrates low acute toxicity, making it a valuable tool for researching T-cell-mediated diseases in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 1370544-73-2
• MW: 339.4
• Formula: C₂₁H₂₂FNO₂
• SMILES: COc1ccc2OCC(CN3CCCC3)=C(c3ccc(F)cc3)c2c1
• Target: Others,TNF,Interleukin,IFNAR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

56949412