AWL-II-38.3

SKU: orb1303663

Description

AWL-II-38.3 is a highly selective and potent small molecule inhibitor targeting the EphA3 receptor tyrosine kinase. It demonstrates minimal off-target activity against Src family kinases or B-Raf. This compound is a valuable research tool for studying EphA3 signaling in cancer biology and angiogenesis, applicable in both cellular and biochemical assays.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1135205-94-5
• MW: 469.42
• Purity: 99.87% (May vary between batches)
• Formula: C₂₃H₁₈F₃N₅O₃
• SMILES: Cc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(NC(=O)c2ccno2)c1
• Target: Ephrin Receptor,Others
• Solubility: DMSO:80 mg/mL (170.42 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.26 mM)

Bioactivity

• In Vitro:
  The structure of AWL-II-38.3 fits into the ATP-binding and substrate-binding pockets of LIMK2 and LIMK1；ALW-II-38.3 forms four direct hydrogen bonds between the ATP-binding cleft of EphA3: the first between the inhibitor oxazole N and the backbone NH of the hinge residue Met702, and the second between the oxazole amide NH and the gatekeeper Thr699 between the side chain hydroxyl group, the third between the benzamide carbonyl oxygen and the main chain NH of Asp764 of the "DFG-motif", the fourth between the inhibitor benzamide NH and the side chain carboxylate necessary for catalysis Glu670 is located in the αC-helix.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ATP, AWL II 38.3, AWLII38.3, AWL-II-38.3, Inhibitor, Ephrin Receptor, EphA3, EphrinReceptor, inhibit, LIMK1, LIMK2

Compound Identifiers

PubChem CID

24880028