Avitinib maleate dihydrate

SKU: orb2945216

Description

Avitinib (Abivertinib) maleate dihydrate is a third-generation, irreversible, orally active selective EGFR inhibitor with IC50 values of 0.18 nM for EGFRL858R and EGFRT790M, and 7.68 nM for wild-type EGFR. Additionally, Avitinib maleate dihydrate functions as a BTK inhibitor, promoting apoptosis in mantle cell lymphoma cells and inhibiting BTK phosphorylation, demonstrating anticancer properties.

Images & Validation

−

Key Properties

−

CAS Number	1822357-78-7
MW	639.631
Formula	C₃₀H₃₄FN₇O₈
SMILES	OC(/C=C\C(O)=O)=O.FC1=C(N2CCN(CC2)C)C=CC(NC3=NC(OC4=CC(NC(C=C)=O)=CC=C4)=C5C(NC=C5)=N3)=C1.O.O
Target	EGFR,BTK,Apoptosis

Storage & Handling

−

Storage	-20°C
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol

EGFR,BTK,Apoptosis

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols