Avicin D

SKU: orb3179941

Description

Avicin D is a plant-derived triterpenoid compound. It induces autophagy (Autophagy) through AMPK activation and inhibits the activities of mTOR and S6 kinase. Avicin D selectively triggers apoptosis (Apoptosis) and downregulates the expression of p-STAT-3, bcl-2, and Survivin. It possesses selective glucocorticoid receptor (Glucocorticoid receptor) modulation properties and inhibits the activation of NF-κB. Additionally, Avicin D exhibits antitumor effects against cutaneous T-cell lymphoma.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 197787-20-5
• MW: 2083.28
• Formula: C₉₈H₁₅₅NO₄₆
• SMILES: C(O[C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O[C@@H]4O[C@@H](CO)[C@H](O)[C@H]4O)[C@H](C)O2)[C@@H](O)[C@H](O)[C@@H](CO)O1)(=O)[C@]56[C@](C=7[C@@](C)(C[C@H]5O)[C@@]8(C)[C@](CC7)([C@]9(C)[C@@](CC8)(C(C)(C)[C@@H](O[C@H]%10[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]%11[C@H](O[C@H]%12[C@H](O)[C@@H](O)[C@H](O)CO%12)[C@@H](O)[C@@H](O)[C@@H](C)O%11)O%10)CC9)[H])[H])(CC(C)(C)[C@@H](OC(/C(=C/CC[C@@](O[C@H]%13[C@H](O)[C@@H](O)[C@H](OC(/C(=C/CC[C@@](C=C)(C)O)/CO)=O)[C@@H](C)O%13)(C=C)C)/CO)=O)C6)[H]
• Target: mTOR,Glucocorticoid Receptor,NF-κB,Apoptosis,S6 Kinase,STAT,AMPK,Autophagy,Survivin,Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

mTOR,Glucocorticoid Receptor,NF-κB,Apoptosis,S6 Kinase,STAT,AMPK,Autophagy,Survivin,Bcl-2 Family