AVE5688

SKU: orb1710358

Description

AVE5688 is a glycogen phosphorylase inhibitor with demonstrated activity against both the b and a isoforms of the enzyme, exhibiting nanomolar binding affinity. This small molecule is a useful research tool for investigating glycogen metabolism and potential therapeutic strategies for type 2 diabetes in biochemical and cellular studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 613260-13-2
• MW: 438.69
• Purity: >99.99% (May vary between batches)
• Formula: C₁₆H₈ClF₅N₂O₅
• SMILES: O(C(F)(F)F)C1=C(NC(NC(=O)C2=C(Cl)C=C(F)C(F)=C2)=O)C=CC(C(O)=O)=C1
• Target: Phosphorylase,Others
• Solubility: DMSO:55 mg/mL (125.37 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (5.7 mM)

Bioactivity

• Target IC50:
  GPa (rabbit muscle):530 nM |GPa (rabbit muscle):915 nM |GPb (rabbit muscle):(kd)170 nM |GPb (rabbit muscle):430 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AVE5688, AVE-5688, AVE 5688, Glycogen phosphorylase (GP), rmGPa, rmGPb

Compound Identifiers

PubChem CID

16070039