Avatrombopag hydrochloride

• Catalog Number: orb1690446
• Category: Small Molecules
• Description: Avatrombopag hydrochloride
• Purity: 98.00%
• Biological Activity: Avatrombopag hydrochloride (AKR-501) is an orally active, nonpeptide agonist of the thrombopoietin (TPO) receptor with an EC 50 of 3.3 nM. It effectively mimics the biological activities of TPO, stimulating platelet production by activating the intracellular signaling system and facilitating the generation of platelets and megakaryocytes from hemopoietic precursor cells. Additionally, Avatrombopag hydrochloride serves as a substrate for cytochrome P450 (CYP) 2C9 and CYP3A.
• CAS Number: [570403-17-7]
• SMILES: Cl.OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(-c2cc(Cl)cs2)c(s1)N1CCN(CC1)C1CCCCC1
• Storage: -20°C
• Note: For research use only