AV457

SKU: orb2945803

Description

AV457 is a potent and selective mTOR inhibitor that effectively suppresses cyst growth in polycystic kidney disease (PKD) organoid models. It reduces phosphorylation of S6 and p70S6K without affecting P-AKT levels, making it a useful tool for studying mTORC1 signaling in PKD and cancer research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2713387-11-0
• MW: 1065.36
• Formula: C₅₅H₈₈N₂O₁₆S
• SMILES: C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)NS(=O)(=O)CCOCCOC
• Target: mTOR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172677376