AV123

SKU: orb1689700

Description

AV123 is a non-cytotoxic, small-molecule inhibitor of RIPK1 (IC₅₀ = 12.12 µM) that selectively blocks TNF-α-induced necroptosis (EC₅₀ = 1.7 µM) without affecting apoptosis. Its application in research extends to studying necroptosis-related pathologies, including ischemia-reperfusion injury, neurodegenerative diseases, and inflammatory conditions, in both cellular and animal models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 233605-81-7
• MW: 234.25
• Formula: C₁₁H₁₄N₄O₂
• SMILES: N(=O)(=O)C=1C=C2C(N=C(NCCCC)N2)=CC1
• Target: Others,RIP kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

10823582