Auxinole

SKU: orb1308623

Description

Auxinole is a potent TIR1/AFB receptor antagonist that blocks auxin signaling by inhibiting the TIR1-IAA-Aux/IAA co-receptor complex formation. This inhibitor is a valuable research tool for studying auxin-mediated processes in both plant developmental biology and in vitro signaling assays.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 86445-22-9
• MW: 321.37
• Purity: 98.93% (May vary between batches)
• Formula: C₂₀H₁₉NO₃
• SMILES: Cc1ccc(C(=O)CC(C(O)=O)c2c[nH]c3ccccc23)c(C)c1
• Target: Others,E1/E2/E3 Enzyme
• Solubility: DMSO:125 mg/mL (388.96 mM);Ethanol:12.5 mg/mL (38.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.45 mM)

Bioactivity

• In Vitro:
  Auxinole is a potent auxin antagonist of TIR1/AFB receptors. It also binds TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and then inhibits auxin-responsive gene expression. Auxinole causes reduction in IAA-triggered depolarization in root hair cells. In addition, Auxinole competitively inhibits various auxin responses in planta. Auxinole (20 μM) also represses the transient increase in [Ca2+]cyt completely, and blocks Ca2+ response.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TIR1/AFB receptor, Inhibitor, inhibit, Auxinole

Compound Identifiers

PubChem CID

13077496