Autotaxin-IN-8

SKU: orb3211354

Description

Autotaxin-IN-8 (Compound 14E) is an orally active inhibitor of Autotaxin, demonstrating an IC50 of 14.2 nM against hAutotaxin. It inhibits Autotaxin activity, suppresses MAPK activation, and reduces LPAR1 and p-ERK1/2 levels. Autotaxin-IN-8 also decreases the phosphorylation of JNK and p38. In a mouse model of pulmonary fibrosis, it reduces collagen deposition and is applicable for studies related to pulmonary fibrosis.

Key Properties

• CAS Number: 3058084-21-9
• MW: 449.90
• Formula: C₂₁H₂₀ClN₉O
• SMILES: N(CCC1=CC=C(Cl)C=C1)C=2N=CC(C=3OC(N4C[C@]5([C@]([C@@H]5C6=CN=NN6)(C4)[H])[H])=NN3)=CN2
• Target: ERK,p38 MAPK,PDE,JNK,LPL Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ERK,p38 MAPK,PDE,JNK,LPL Receptor