Autocamtide-2-related inhibitory peptide

SKU: orb1218666

Description

Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.

Key Properties

• CAS Number: 167114-91-2
• MW: 1822.1
• Purity: >98% (HPLC)
• Formula: C₈₀H₁₄₃F₃N₂₂O₂₂
• SMILES: O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCCN)NC([C@@H](N)CCCCN)=O)=O)=O)=O)=O
• Target: CaMK
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  It is found that Autocamtide-2-related inhibitory peptide (a novel synthetic peptide ATP) is a potent inhibitor of CaM-kinase II with an IC50 of 40 nM, which is active in the presence or absence of Ca2+/calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93, respectively, under the assay condition used.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CaMK