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Aurora kinase-IN-8

SKU: orb3173105

Description

Aurora kinase-IN-8 is a bioavailable inhibitor of Aurora kinases, with IC50 values of 2.8 nM for Aurora A kinase and 28.1 nM for Aurora B kinase. It disrupts spindle formation, causes G2/M phase arrest, and induces apoptosis (apoptosis). This compound is applicable in cancer research, including studies on triple-negative breast cancer.

Research Area

Cell Biology, Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number1911629-44-1
MW425.54
FormulaC25H27N7
SMILESN(C=1C2=C(C=C(C=C2)N3CCN(C)CC3)N=C(/C=C/C4=CC=CC=C4)N1)C=5C=C(C)NN5
TargetAurora Kinase,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information