Auristatin E

SKU: orb1308627

Description

Auristatin E is a potent microtubule-disrupting cytotoxin that inhibits tubulin polymerization, arresting cell division. As the payload (MMAE) in antibody-drug conjugates, it is widely used in oncology research for evaluating antitumor efficacy in both in vitro and in vivo models.

Research Area

Signal Transduction

Key Properties

• Target: Microtubule Associated,ADC Cytotoxin
• CAS Number: 160800-57-7
• MW: 732.01
• Purity: 98.75% (May vary between batches)
• Formula: C₄₀H₆₉N₅O₇
• SMILES: [H][C@]1(CCCN1C(=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C)[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADC Payload, ADC Cytotoxin, ADCCytotoxin, Auristatin, Auristatin E, inhibit, Microtubule Associated, Microtubule/Tubulin, MicrotubuleAssociated, Inhibitor

Compound Identifiers

PubChem CID

11498622