Aurintricarboxylic acid

SKU: orb1299026

Description

Aurintricarboxylic acid is a potent small-molecule inhibitor of nucleases, including ribonuclease and topoisomerase II, acting by blocking nucleic acid-enzyme binding. It is widely used in biochemical research to study nucleic acid metabolism and protein interactions in both in vitro and cell-based assays.

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 4431-00-9
• MW: 422.34
• Purity: 85.00% (May vary between batches)
• Formula: C₂₂H₁₄O₉
• SMILES: OC(=O)C1=CC(C=CC1=O)=C(c1ccc(O)c(c1)C(O)=O)c1ccc(O)c(c1)C(O)=O
• Target: Topoisomerase,P2X Receptor,Apoptosis,MicroRNA,Influenza Virus
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.47 mM);DMSO:125 mg/mL (295.97 mM)

Bioactivity

• Target IC50:
  P2X3 (rat):72.9 nM|MicroRNA:0.47 μM|P2X1 (rat):8.6 nM
• In Vitro:
  Aurintricarboxylic acid (ATA) is a known Stp1 inhibitor with an IC50 of 1.03 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Topoisomerase II, Topoisomerase, rP2X1, rP2X3, receptor, sensory, P2X, P2X Receptor, P2XReceptor, P2XRs, TWEAK, TWEAK-Fn14, anti-influenza, Apoptosis, Aurintricarboxylic acid, ATP-gated, ATA, cough, chronic, neurotransmission, neuropathic, MicroRNA, miRNA, NSC 4056, NSC4056, NSC-4056, pain, inhibit, InfluenzaVirus, Influenza Virus, Inhibitor, family, Fn14, glioblastoma

Compound Identifiers

PubChem CID

2259