Aurantiamide acetate

SKU: orb1297667

Description

Aurantiamide acetate

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 56121-42-7
• MW: 444.52
• Purity: 99.68%
• Formula: C₂₇H₂₈N₂O₄
• SMILES: CC(=O)OC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1
• Target: Cysteine Protease
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (5.62 mM);DMSO:55 mg/mL (123.73 mM)

Bioactivity

• Target IC50:
  Cathepsin B:49 μM|Cathepsin L:12 μM
• In Vivo:
  Aurantiamide acetate reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling.
• In Vitro:
  Aurantiamide acetate decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 μM. Aurantiamide acetate inhibited cysteine proteinases, in particular, cathepsin L and B with IC50 of 12 microM and 49 microM, respectively.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cysteine Protease, CysteineProtease, adjuvant-arthritic, cathepsin L, Cathepsin L, Cathepsin B, Cathepsin, Antifection, Asperglaucide, Aurantiamide, Aurantiamide acetate, Aurantiamide Acetate, inflammatory diseases, inhibit, Inhibitor, Piper aurantiacum

Compound Identifiers

PubChem CID

10026486