AU1235

SKU: orb1309964

Description

AU1235 is a small molecule compound that inhibits Mycobacterium tuberculosis growth. It is a research tool for studying tuberculosis pathogenesis and evaluating potential therapeutic strategies in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1338780-86-1
• MW: 324.34
• Purity: 99.87% (May vary between batches)
• Formula: C₁₇H₁₉F₃N₂O
• SMILES: Fc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c(F)c1F
• Target: Antibacterial
• Solubility: DMSO:3.25 mg/mL (10.02 mM)

Bioactivity

• In Vitro:
  AU1235 has a MIC of 0.1 μg/mL (0.3 μM) (minimum bactericidal concentration of 0.1 μg/mL. AU1235 is similarly active against MDR clinical isolates of M. tb displaying resistance to isoniazid, rifampicin, and pyrazinamide in addition to streptomycin, fluoroquinolones and/or ethambutol. AU1235 also inhibits Mycobacterium smegmatis and Mycobacterium fortuitum (MICs: 3.2 to 6.4 μg/mL). AU1235 (10 times MIC) does not increase the killing effect within the first 7 days indicating that the killing is time-dependent rather than concentration-dependent. In an anaerobic model involving non-replicating M. tb H37Rv bacilli, AU1235 at 10 μg/mL shows no detectable activity suggesting that it acts on a biosynthetic pathway required for active bacterial multiplication. AU1235 does not inhibit the biosynthesis of mycolic acids per se but specifically their ability to be transferred onto their cell wall and outer membrane acceptors.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cell, AU1235, AU-1235, AU 1235, Bacterial, Inhibitor, inhibit, Mycobacterium, Mycobacterium tuberculosis, MmpL3, wall, synthesis, transport, tuberculosis

Compound Identifiers

PubChem CID

54752297