ATX L1

SKU: orb3033120

Description

L1 is a biodegradable, branched self-immolative lipid optimized for ​​high-efficiency mRNA delivery​​. Its disulfide-based architecture enables rapid glutathione-triggered degradation in the cytosol (liver half-life: 4.2 days), promoting rapid clearance while maintaining serum stability. In vivo, L1 achieves ​​exceptional mRNA translation​​, producing twice the hEPO protein levels of the clinically approved MC3 lipid at 0.1 mg/kg. Its apparent pKa (6.57) facilitates efficient endosomal escape without compromising safety: even at 5 mg/kg, L1 causes no significant body weight loss or sustained inflammation. Structural features (C7 alkyl tails, carbamate linker) balance potency and biodegradability, making L1 ideal for mRNA vaccines and protein-replacement therapies.

Key Properties

• MW: 831.35
• Purity: >98%
• Formula: C₄₆H₉₀O₆N₂S₂
• SMILES: CCCCCCCC(CCCCCCC)OC(=O)CCCN(CCCC(=O)OC(CCCCCCC)CCCCCCC)C(=O)OCCSSCCCN(C)C

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only