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ATX inhibitor 26

SKU: orb3028013

Description

ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. It effectively inhibits cell migration and collagen gel contraction. Additionally, ATX inhibitor 26 demonstrates significant antifibrotic activity, reducing collagen deposition in a Bleomycin (BLM)-induced pulmonary fibrosis model.

Research Area

Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number2940248-11-1
MW452.30
FormulaC18H19Cl2N7O3
SMILESO=C(OCC=1C=C(Cl)C=C(Cl)C1)N2CCC(C3=NN=C(O3)NCC4=CN=NN4)CC2
TargetERK,PDE,JNK,p38 MAPK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

ATX inhibitor 26 (orb3028013)

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