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ATR/PARP1-IN-1

SKU: orb3135090

Description

ATR/PARP1-IN-1 is a dual inhibitor of ATR/PARP1, exhibiting an IC50 of 17.3 nM for ATR and 0.38 nM for PARP1. It effectively reduces cell viability, induces apoptosis, and causes DNA damage. In triple-negative breast cancer (TNBC) models, ATR/PARP1-IN-1 significantly inhibits colony formation, migration, and invasion. Additionally, in MDA-MB-468 xenograft mouse models, it suppresses tumor growth without significant changes in body weight.

Research Area

Epigenetics & Chromatin; Cell Biology

Images & Validation

Key Properties

TargetATM/ATR,PARP,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

ATR/PARP1-IN-1 (orb3135090)

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