Atranorin

SKU: orb1297458

Description

Atranorin is a lichen-derived small molecule with demonstrated antinociceptive and anti-inflammatory properties. Its context-dependent redox activity, acting as both pro-oxidant and antioxidant, contributes to cytoprotective effects against H₂O₂-induced oxidative stress in cellular models, supporting research in pharmacology and toxicology.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 479-20-9
• MW: 374.34
• Purity: 99.57% (May vary between batches)
• Formula: C₁₉H₁₈O₈
• SMILES: COC(=O)c1c(C)cc(OC(=O)c2c(C)cc(O)c(C=O)c2O)c(C)c1O
• Target: Endogenous Metabolite|||Ras|||NO Synthase
• Solubility: DMSO:Slightly soluble

Bioactivity

• In Vitro:
  Three lichen secondary metabolites Atranorin (1), evernic acid (2), and usnic acid (3), were evaluated for their in vitro clastogenic and antiproliferative effects on human lymphocytes using the cytochalasin-B blocked micronucleus (CBMN) assay at concentrations of 2 microg/mL, 4 microg/mL and 6 microg/mL of final culture solution. Atranorin at concentrations of 2 microg/mL and 4 microg/mL decreasing the frequency of MN only for 11.1% and 1.8%, while in concentration of 6 microg/mL increases the frequency of MN for 9.6 %
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-tumor, AP-1, Atranorin, metabolite, NO Synthase, NOSynthase, Lichen, inhibit, EndogenousMetabolite, Endogenous Metabolite, Inhibitor, β-catenin, STAT, secondary, Wnt, Ras

Compound Identifiers

PubChem CID

68066