ATR-IN-20

SKU: orb1744285

Description

ATR-IN-20 is a highly potent dual inhibitor of ATM/ATR (IC50=3 nM) and mTOR (IC50=18 nM) with significant selectivity over related kinases. It demonstrates favorable oral bioavailability (F=30%) and exhibits promising anticancer activity in both cellular and animal models, supporting its use in DNA damage response and oncology research.

Research Area

Epigenetics & Chromatin, Molecular Biology, Signal Transduction

Key Properties

• MW: 545.65
• Formula: C₂₉H₃₁N₅O₄S
• SMILES: C[C@@H]1COCCN1C2=NC(=NC3=C2CN(C3(C)C)C(=O)C4=CC(=CC=C4)S(=O)(=O)C)C5=C6C=CNC6=CC=C5
• Target: Others,mTOR,ATM/ATR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166176974