ATR-IN-14

SKU: orb1688229

Description

ATR-IN-14 (compound 1) is a potent and selective ATR kinase inhibitor, achieving 98.03% inhibition of ATR signaling at 25 nM and an IC50 of 64 nM in LoVo colorectal cancer cells. This small molecule is a valuable chemical probe for studying DNA damage response pathways in oncology research, applicable in both in vitro and in vivo experimental models.

Research Area

Epigenetics & Chromatin, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 2765785-88-2
• MW: 393.42
• Formula: C₂₀H₂₀FN₇O
• SMILES: FC=1C2=C(C(=NC1)C=3C=CNN3)N=C(C=C2C=4N(C)N=CC4)N5[C@H](C)COCC5
• Target: Others,ATM/ATR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163408900