ATN-161 trifluoroacetate salt

SKU: orb1309969

Description

ATN-161 TFA salt is a selective integrin α5β1 antagonist that blocks angiogenesis. It has demonstrated efficacy in preclinical studies, inhibiting tumor growth and metastasis in murine models, particularly for liver metastases, and improving survival outcomes.

Research Area

Signal Transduction

Key Properties

• CAS Number: 904763-27-5
• MW: 711.67
• Purity: 99.98% (May vary between batches)
• Formula: C₂₅H₃₆F₃N₉O₁₀S
• SMILES: OC(=O)C(F)(F)F.CC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(N)=O
• Target: Integrin
• Solubility: H2O:5.95 mg/mL (8.36 mM);DMSO:Slightly soluble

Bioactivity

• In Vivo:
  Initial tests on α5β1-negative human colon cancer xenografts (HT29) show ATN-161 significantly decreases tumor weight and vessel density . Administering ATN-161 post-laser photocoagulation effectively suppresses choroidal neovascularization (CNV) leakage and new blood vessel formation, achieving results comparable to those with AF564 .
• In Vitro:
  The co-administration of ATN-161 and 5-FU markedly reduces tumor cell growth more effectively than either treatment alone or the control. Additionally, this combined approach markedly elevates the levels of apoptotic (TUNEL-positive) tumor cells, a result not observed with single-agent treatments. Furthermore, ATN-161 demonstrates a 21% reduction in endothelial cell (EC) numbers after 48 hours compared to controls, highlighting its effectiveness. Importantly, ATN-161 also impedes VEGF-induced endothelial cell migration and capillary formation, although it does not affect their proliferation. It significantly decreases endothelial cell migration towards VEGF in a dose-dependent manner, beginning at 100 nM (P<0.001 vs. VEGF group), showcasing its potential in inhibiting angiogenesis.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ATN 161, ATN 161 Trifluoroacetate, ATN 161 trifluoroacetate salt, ATN161, ATN-161, ATN-161 TFA, ATN-161 TFA salt, ATN161 Trifluoroacetate, ATN-161 Trifluoroacetate, ATN161 trifluoroacetate salt, inhibit, Inhibitor, Integrin, Integrin α5β1

Compound Identifiers

PubChem CID

92044380