ATM Inhibitor-11

SKU: orb2802510

Description

ATMInhibitor-11 (Compound 1) is a potent, brain-penetrant ATM kinase inhibitor with single-digit nanomolar IC50 values against ATM and KAP1 phosphorylation. It demonstrates favorable in vivo exposure and has shown antitumor efficacy in NCI-H441 xenograft models, supporting its use in oncology research, particularly for studying DNA damage response pathways.

Research Area

Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2878473-51-7
• MW: 492.59
• Formula: C₂₇H₃₃FN₆O₂
• SMILES: O=C1N(C=2C=NC=3C=C(F)C(=CC3C2N1C(C)C)C=4C=NC(OCCCN5CCN(C)CC5)=CC4)C
• Target: ATM/ATR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176419312